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KMID : 0606920070150040218
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Biomolecules & Therapeutics
2007 Volume.15 No. 4 p.218 ~ p.223
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Different Pattern of p27kip1 and p21cip1 Expression Following Ex Vivo Activation of CD8+ T Lymphocytes
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Kim Sung-Jin
Lee Hyeon-Woo
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Abstract
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T cell proliferation is a pivotal to an effective immune response. Cyclin-dependent kinase (cdk) inhibitor, p27kip1 is degraded to initiate T cell expansion. In this study, we show that although the expression of p27kip1 protein was down-regulated, that of p21cip1, another cdk inhibitor, was up-regulated in CD8+ T cells following in vitro stimulation. Ex vivo gB antigen-stimulation following HSV immunization increased p21cip1 positive cells that co-expressed IFN-γ. Moreover, p21cip1 was co-expressed with IFN-γ in E7 antigen-stimulated CD8+ T cells, whereas p27kip1 was not. Our findings imply a role of p21cip1 proteins in antigen-induced effector CD8+ T cells differentiation in vivo.
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KEYWORD
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p27kip1, p21cip1, effector CD8+ T cells, differentiation, virus antigens
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